At a cost of $3 billion, supported by the National Institutes of Health under the Department of Health and Human Services, the Human Genome Project (HGP) completed the sequence of the human genome in 2000. Despite early promises, to date there have been minimal advancements in genetic-based therapies for chronic degenerative diseases that are crippling America.

Since 1980 the prevalence of obesity and type 2 diabetes have doubled and tripled, respectively, in the USA and similar trends are now seen throughout the world. Over the past 62 years, the US has fallen from first to last place in longevity among 17 wealthy countries around the world due to the enormous increase in metabolic disease, including diabetes and heart disease.

Recent breakthroughs in science have shown that nutritional factors play a significant role in the spread of metabolic disease, including obesity, type-2 diabetes, lipid disorders, cardiovascular disease, brain disease (dementia and Alzheimer’s Disease), autoimmune diseases and cancer.

The specific aims of the Institute to Improve World Health, including the La Jolla Project, will demonstrate how dietary deficiencies compromise metabolic health through poor nutrition that leads to “Selective Protein Deficiency Syndrome.”



“We have identified protein candidates that appear to be responsible, in large part, for the diet-related development of (i) obesity, (ii) Type-2 diabetes, (iii) pancreatitis, (iv) toxin-induced liver cancer, (v) colon cancer, (vi) cancers due to loss of DNA repair and P53 tumor suppression, (vii) aging syndromes, (viii) telomere dysfunction leading to premature aging, (ix) age-related sarcopenia (x) Dementia syndromes and (xi) anandamide regulation of well-being and procreation.

Our research has also provided insight into how to prevent and treat these nutritional defects.”

George A. Scheele, M.D.
December 15, 2015


Food chain signals are intimately involved in the evolution of vertebrates and mammals as they control the feedback mechanisms of hunger and satiety, which are important in reproduction and evolution. Without understanding the importance of hunger and satiety signals modern societies will suffer from epidemics of diet-related metabolic disease, including obesity, type 2 diabetes, lipid disorders, cardiovascular disease, brain disease, autoimmune disorders, and cancer.

A full understanding of satiety and hunger signals in the food chain will provide modern societies with the intellectual tools to optimize health and avoid the expanding epidemics of chronic degenerative disease, including the Metabolic Syndrome, which is associated with the metabolic diseases described above. The Institute to Improve World Health has achieved a breakthrough in understanding food chain signals that impact on multiple diseases that afflict the modern world.

The activities of the Institute to Improve World Health will show the breakthrough interplay of basic science discoveries with healthcare solutions that have the potential to stem the tide of metabolic disease in today’s world. Only through the integration of cell biology, molecular biology and molecular medicine can we solve the enormous problems of today’s malnutrition for the benefit of world health and productivity.



The specific purpose of the nonprofit corporation is to apply the recent breakthroughs in scientific research to define the nutritional factors that lead to chronic degenerative diseases associated with the metabolic syndrome and to conduct intensive educational and advocacy programs showing how dietary habits and innovative, patent-protected health-care products can be used to improve metabolic health and lower health-care costs around the world.

Our vision is to use these innovative nutritional concepts and products to make possible dramatic global improvements in human health and wellness over the next 10 years.



Alternative approaches to ensure health and wellness will effect social change throughout the world to relieve immense suffering and significantly lower health-care costs by focusing on:

  • Healthy Lifestyles with increased satiety, improved diet, exercise, sleep, attitude, and less dependency on sugar, caffeine and alcohol.
  • Weight Control with lower body weight, improved body definition (lower fat/muscle ratio), and increased pep, energy, activity, stamina, endurance and performance.
  • Metabolic Health with lower levels of blood cholesterol, triglycerides, sugar and less metabolic disease, including overweight disorders, hypertension, type 2 diabetes, cardiovascular disease, brain disease, cancer, osteoarthritis, and gallbladder, liver & kidney disease.
  • Aging Health with increased longevity and quality of life evidenced by reduced chronic degenerative disease and enhanced feelings of comfort, satisfaction, and well-being.

The key to understanding these four areas of health and wellness has been articulated in Dr. Scheele’s recent book, The Obesity Cure, and will be broadly extended in The La Jolla Project in the Strategy Statement.



Dr. George A. Scheele serves as the President of The Foundation and Institute to Improve World Health.

Dr. Scheele is a world-renowned physician, inventor, author and two-time Nobel Associate, who has pioneered in understanding the critical role of amino acids in regulating metabolic health and body weight. He recently introduced Factor4 Weight Control®, a unique, patent-protected formulation of essential ingredients to treat the four nutritional traps that lead to overweight disorders and obesity.

As a graduate of Princeton University and Johns Hopkins Medical School he served as Professors of Medicine on the faculties of The Rockefeller University, Yale University School of Medicine and Harvard Medical School. Dr. Scheele invented new concepts and techniques which “cracked the code” in understanding how Power Amino Acids® correct the deficiencies in amino acids, positive-charged proteins, and metabolic pathways that normalize body weight and restore metabolic health.

A pioneer in the development of the fields of Cell Biology and Molecular Biology and their impact on understanding chronic human diseases, he participated in work that won two Nobel Prizes in Medicine awarded in 1974 and 1999.

As a leader in nutritional science and medical research with 40 years of innovative scientific research and 10 years of breathtaking achievements in the fields of obesity and metabolic disease, Dr. Scheele’s passion has always been to “Make the World a Better Place”. After moving to La Jolla in 1998, he has utilized his vast experience to develop superior health-care products for individuals living in today’s fast-paced world.

Dr. Scheele is currently the Founder, President, and CEO of NovaLife, Inc. a San-Diego based biotech company that has pioneered in the development of innovative health-care products for people who suffer from obesity and metabolic diseases, including diabetes, lipid disorders, cardiovascular disease, brain disease, autoimmune disorders, and aging.



Dr. Scheele has posted a series of articles on the medical benefits and scientific principles underlying Factor4 Weight Control® success on These articles summarize the numerous medical and scientific breakthroughs in Factor4 Health based on Dr. Scheele’s innovative research. These include:

  • Twelve medical articles on the benefits of Factor4 in specific metabolic diseases, including Obesity, Type 2 Diabetes, Lipid Disorders, Cardiovascular Disease, Aging, Loss of Hormones, Sleep Deprivation, Depression, Memory/Focus, Chronic Stress, Anxiety/Mood Disorders, and Autoimmune Diseases.
  • Six articles on the scientific principles that underlie the therapeutic benefits of Factor4.
  • One paper, which chronicles the clinical success of Factor4 Weight Control® in weight loss health
  • Two media articles, including (i) The Obesity Cure and (ii) The Perfect Storm in Health Care Encircling the Globe